Complex Regional Pain Syndrome (CRPS) is a chronic nerve pain where there is often a nerve injury but it has gone undiagnosed due to either the clinicians’ lack of understanding about peripheral nerve anatomy or due to the complexity of the peripheral nerve injuries that follows soft-tissue or bone injury diagnosed (type I) or undiagnosed peripheral nerve injury or (type II) which is also ‘neuropathic’ pain but in this case the nerve injury has been identified. Other manifestations include autonomic changes (eg. sweating, vasomotor abnormalities), motor changes (eg. weakness, dystonia), and trophic changes (eg. skin or bone atrophy, hair loss, joint contractures). Diagnosis is clinical. Treatment includes but not limited to medications, physical therapy, and sympathetic blockades. CRPS effects children as well as adults. While not everyone with CRPS will find relief from their pain, there are exciting, new options which can be very successful in relieving nerve pain if the underlying peripheral nerve problem can be identified and addressed either with conservative measures or surgery.